Evidence for bradykinin as a stimulator of thirst

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Evidence for bradykinin as a stimulator of thirst.

Angiotensin-converting enzyme inhibition (ACEI) with captopril has been shown to increase water intake and urine output in rats, but the mechanism is unknown. ACEI impairs the conversion of ANG I to ANG II, a dipsogenic hormone, and impairs the degradation of bradykinin. The goal of this study was to examine the role of bradykinin in the polydipsia and polyuria associated with ACEI. Male Spragu...

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Preparation of a Photoactivable Ligand for Bradykinin Receptors

ABSTRACT Most of physiological effects of bradykinin is due to its effect on bradykinin B2 receptors. There is no reports of preparation of a photoactivatable analogue of bradykinin reactive with sloubilized bradykinin B2 recpetors. Photoactivatable radioactive ligands are powerful tools in purification of receptors. In this study we report preparation of a photoactivatable iodinatable analo...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Renal Physiology

سال: 2004

ISSN: 1931-857X,1522-1466

DOI: 10.1152/ajprenal.00243.2003